Scientific collaborator – Stimulating regulatory uptake of an innovative platform for cardiotoxicity evaluation
Sciensano

Scientific collaborator – Stimulating regulatory uptake of an innovative platform for cardiotoxicity evaluation

Sciensano
  • Fixed-term Position (From 6 to 36 months)
  • Ixelles (Belgium)
  • Published on August 27 2021

The Company

Sciensano can count on more than 700 staff members who commit themselves, day after day, to achieve our motto: Healthy all life long.

As our name suggests, science and health are central to our mission. Sciensano’s strength and uniqueness lie within the holistic and multidisciplinary approach to health. More particularly we focus on the close and indissoluble interconnection between human and animal health and their environment (the “One health” concept). By combining different research perspectives within this framework, Sciensano contributes in its unique way to everybody’s health.

For this, Sciensano builds on the more than 100 years of scientific expertise of the former Veterinary and Agrochemical Research Centre (CODA-CERVA) and the ex-Scientific Institute of Public Health (WIV-ISP).

 For more information on our projects and activities: https://www.sciensano.be.

Description of the job

You will be responsible for the work package ‘Regulatory uptake’ within the European research project ‘environmentAL Toxicology of chEmical mixtuRes through aN innovATIVE platform based on aged cardiac tissue model‘ (ALTERNATIVE).
You will join the service Risk and Health Impact Assessment. You will collaborate with different international partners of the ALTERNATIVE project and in particular with the Medical University of Innsbruck.

ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their biotransformation products. The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way. The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool.
Within the project, Sciensano is responsible for ensuring that the developed platform meets the regulatory needs and to stimulate its regulatory uptake. To this extent, the platform will be developed within the adverse outcome pathway framework and its place within an integrated approach for testing an assessment will be defined.

Your tasks will include

  • Collection of information on chemicals inducing cardiotoxicity;
  • Documentation of regulatory needs for cardiotoxicity methods and data; 
  • Design of novel and/or extension of existing AOPs for cardiotoxicity;
  • Linking of information collected with the ALTERNATIVE platform to the AOPs;
  • Designing the outline of an IATA for cardiotoxicity;
  • Drafting of guidance for regulatory use of cardiotoxicity data collected with the ALTERNATIVE platform;
  • Participating in project meetings;
  • Presentation of research results at congresses and valorisation in peer reviewed publications.

Profile 

PhD in Toxicology.
Experience with the AOP concept and/or IATA development is an asset.
Willing to work independently in the context of the research project and to collaborate with different European partners.
Interest in new approach methodologies.

Excellent knowledge of English

Behavioral competencies:

  • Result and solution-oriented working
  • Precise, enterprising and stress resistant
  • Good communication skills  (incl. written reporting, scientific presentation)
  • Able to work independently

We offer

A challenging position in a renowned scientific institute
Fixed-term contract (3 years)
Salary range: SW21
Benefits: free or 100% reimbursement for commuting by public transport; hospital/group insurance; meal vouchers; various benefits via FED+ (www.fedplus.be); social benefits
Other: flexible working hours of 38 hours/week; teleworking and training opportunities

Contact
Send your application via our website https://www.sciensano.be.

Do you have questions about this position or would you like more information?
Contact the Jobcenter via [email protected].