Doctoral scholarship - Viral pseudoparticles & immunological mechanism
Sciensano

Doctoral scholarship - Viral pseudoparticles & immunological mechanism

Sciensano
  • PhD / Postdoc / Thesis (36 months (Start date Nov. 2021))
  • Brussels (Belgium)
  • Published on September 9 2021

Sciensano is the institute created by the merger of the Scientific Institute of Public Health (WIV-ISP) and the Veterinary and Agrochemical Research Centre (CODA-CERVA). Our institutes have joined forces to better understand human and animal health. Sciensano supports health policy through innovative scientific research, analyses, surveillance and expert advice. Together with more than 800 employees, we work on more than 100 scientific projects funded by governments, Belgian or international partners and clients. In this way, we contribute to a longer healthy life for everyone.
For more information about our projects and activities: https://www.sciensano.be.

The PSEUDOVIR-project aims to generate infectious pseudotyped lentiviral particles for mumps, measles and Newcastle disease and to develop neutralization assays using these pseudoparticles. Based on these assays, (i) the human immunity for measles and mumps will be assessed in a Belgian cross-sectional study, and (ii) the poultry immunity for Newcastle Disease Virus (NDV) will be assessed in Belgian professional flocks. Furthermore, the level of cross-protection of vaccine-induced neutralizing antibodies for circulating mumps-, measles- and NDV-strains in Belgium will be measured. 

The work involves molecular (plasmid generation and transfection) and immunological (neutralization testing) work in L2 and L3 labs.

The project is a collaboration between 3 Sciensano labs experienced in viral immunology. The candidate will work in the service Immune response, the service Viral diseases (both SD Infectious diseases in humans) and the service Avian virology and immunology (SD Infectious diseases in animals).

Our ideal candidate has a master degree in a relevant area (bio-medical sciences, molecular biology or engineering, veterinary sciences,…), is interested in viral immunology and a hands-on experience in basic immunological and molecular techniques and in cell culture. 

We offer a doctoral grant of 2000 euro/month (48 months)